Process for the isolation of Z and E gugulsterones from aerial b

Details Process for the isolation of Z and E gugulsterones from aerial b Process for the isolation of Z and E gugulsterones from aerial b

1999-03-05

2000-07-11

Kunz, Gary L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

4241961, A61K 3157, C07J 1300

Patent

active

060868899

ABSTRACT:
A process for the isolation of a lipid fraction containing Z & E guggulsterones useful as cholesterol lowering drug, which comprises soaking/soxhlet extracting the powdered aerial part of the plant C. wightii with a non polar solvent, filtering/deanting the extract, soaking the material again in a polar solvent, filtering and concentrating the extracted material under reduced pressure as to obtain a thick viscous extract, and subjecting the thick viscous extract to gel filteration/silica gel chromatography to obtain Z & E ketosteroid containing lipid fraction exhibiting hypolipidemic activity.

REFERENCES:
Bhatt et al., "Enhancement of Oleo-Gum Resin Production in Commiphora wightii by Improved Tapping Technique", Current Science, Apr. 5, 1989, vol. 58, No. 7, pp. 349-357.
Satyavati, Medicinal Plants of India, vol. I, pp. 270-276, 1976.
Patil et al., "Chemistry of Ayurvedic Crude Drugs", Tetrahedron 28, 2341, 1972.
Chemical Abstracts 85:256t, 1976.
Chemical Abstracts 116:67242n, 1992.

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