Process for the isolation of the polyvalent proteinase inhibitor

Details Process for the isolation of the polyvalent proteinase inhibitor Process for the isolation of the polyvalent proteinase inhibitor

1979-02-12

1980-02-26

Hart, Charles N.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 95, 424177, 252426, C07G 1700

Patent

active

041905733

ABSTRACT:
What is disclosed is a method for the isolation of the polyvalent proteinase inhibitor from aqueous extracts of animal organs by adsorbing the inhibitor from its aqueous solutions at pH 0.5 to 10.5 on an ion exchanger containing functional sulfonate or phosphonate groups and eluting it with water or a salt solution at pH 1 to pH 13, the exchanger having a particle size from 0.03 to 0.08 mm or, in case the ion exchanger is a copolymer gel of ethene-sulfonate and acrylamide, having a particle size from 0.03 to 3 mm preferably from 0.06 to 0.3 mm.

REFERENCES:
patent: 3002887 (1961-10-01), Zilliken
patent: 3003918 (1961-10-01), Sanders
patent: 3181997 (1965-05-01), Schultz
patent: 3308026 (1967-03-01), Schultz
patent: 3468760 (1969-09-01), Foss
patent: 3558773 (1971-01-01), Schultz
patent: 3682835 (1972-08-01), Louderback
patent: 3809748 (1974-05-01), Khouw
patent: 3855196 (1974-12-01), Matsukawa
patent: 3893890 (1975-07-01), Wurzburg
patent: 3912704 (1975-10-01), Singh
Chem. Abstracts, vol. 83-3271.

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