Process for the isolation of lovastatin

Details Process for the isolation of lovastatin Process for the isolation of lovastatin

2006-05-30

2006-05-30

Lilling, Herbert J. (Department: 1651)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

C435S123000

Reexamination Certificate

active

07052886

ABSTRACT:
The process for the preparation and isolation of the hypolipaemic active substance lovastatin in substantially pure form having a purity of at least 95% which comprises lactonizing the mevinolinic acid to lovastatin in a totally aqueous medium.

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Blackwell C M et al, “Total Synthesis of Dihydromevinolin and a Series Related 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors”, Journal of Organic Chemistry, American Chemical Society, Washington, DC, US, vol. 57, No. 21, 1992, pp. 5596-5606.

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