Process for the isolation of crystalline imipenem

Details Process for the isolation of crystalline imipenem Process for the isolation of crystalline imipenem

2007-07-10

2007-07-10

Berch, Mark L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

10478624

ABSTRACT:
The present invention relates to a cost effective and industrially advantageous process for the preparation of imipenem of high purity comprising the steps of treating an aqueous solution containing imipenem with an organic solvent, wherein the imipenem is not lyophilized; and isolating the pure crystalline imipenem monohydrate from the reaction mixture thereof.

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Connolly et al., “Freeze Crystallization of Imipenem”,Journal of Pharmaceutical Sciences, 85(2):174-177 (1996).

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