Process for the isolation of an active principle from azadiracht

Details Process for the isolation of an active principle from azadiracht Process for the isolation of an active principle from azadiracht

1996-02-05

1998-03-24

Witz, Jean C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

A61K 3578

Patent

active

057309868

ABSTRACT:
A new process for isolation of a phenolic glycoside from Neem bark aqueous extract. This phenolic glycoside is highly potent in inhibiting gastric acid secretion and stress-induced gastric ulceration. The aqueous extract is lyophilised and the powder is extracted with petroleum ether. The insoluble residue is extracted with solvents of increasing polarity and the final residue is subjected to HPLC using a reverse phase column to isolate the active compound.

REFERENCES:
patent: 4515785 (1985-05-01), Shimizu et al.
patent: 5391779 (1995-02-01), Lidert
patent: 5420318 (1995-05-01), Lidert et al.

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