Process for the isolation of a nontoxinogenic vibrio cholerae st

Details Process for the isolation of a nontoxinogenic vibrio cholerae st Process for the isolation of a nontoxinogenic vibrio cholerae st

1999-02-03

2000-08-22

Bui, Phuong T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4242341, 424 934, 424 932, 43525221, 4352523, 4351723, 435248, 435909, A61K 29106, C07H 2104, C07K 1428, C12N 121

Patent

active

061068438

ABSTRACT:
A process for the isolation of nontoxinogenic V. cholerae strain and a process for preparing a cholera vaccine from said V. cholerae strain, said process comprising (a) isolating V. cholerae from the stool of a patient suffering from cholera by spreading the stool on a selector medium specific for V. cholerae, (b) separating the non-toxinogenic V. cholerae strain from the population of the V. cholerae strains isolated in step (a), and (c) incorporating immunogenic cholera toxin (ctx) B subunit gene into the chromosome of the strain by conventional methods to produce the vaccine.

REFERENCES:
patent: 4264737 (1981-04-01), Murphy
patent: 4882278 (1989-11-01), Mekalanos
patent: 5399494 (1995-03-01), Kaper et al.
patent: 5631010 (1997-05-01), Mekalanos
Dasgupta et al. Vaccine, vol. 12, No. 4, 1995, p. 359-364.

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