Process for the isolation of a major harmful oxidant from...

Details Process for the isolation of a major harmful oxidant from... Process for the isolation of a major harmful oxidant from...

2005-08-16

2005-08-16

Walls, Dionne A. (Department: 1731)

Tobacco

Tobacco users' appliance

Device used for smoking

C073S023330, C073S023310, C073S023200, C073S028010

Reexamination Certificate

active

06929012

ABSTRACT:
The components of cigarette smoke, known until now, do not explain the overwhelming hazardous effects of smoking; this invention describes the isolation, identification and procedures for determination of the structure, properties and assay of a relatively stable major harmful oxidant (cs-oxidant) present in the cigarette smoke, the content of which is about 190±10 μg per cigarette; the cs-oxidant alone almost quantitatively accounts for the oxidative damage of proteins produced by the aqueous extract of whole cigarette smoke, it is also responsible for the oxidative damage of DNA; since the cs-oxidant is relatively stable, it further explains the deleterious effects of the side stream smoke and passive smoking; a number of chemical compounds/agents including vitamin C have been found to prevent the cs-oxidant induced protein oxidation in vitro.

REFERENCES:
patent: 4140033 (1979-02-01), Pillsbury, Jr. et al.
patent: 5854000 (1998-12-01), Bucala et al.

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