Process for the isolation and purification of monosialogangliosi

Details Process for the isolation and purification of monosialogangliosi Process for the isolation and purification of monosialogangliosi

1991-07-15

1992-04-28

Sever, Frank

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210652, B01D 6114

Patent

active

051086131

ABSTRACT:
By ultrafiltration of an aqueous solution wherein there have been formerly dissolved alfa-cyclodextrin and a raw lipidic mixture, the latter characterized in that it contains monosialoganglioside (GM1) either as the sole ganglioside or otherwise in a prevailing quantity over the other associated gangliosides, and after the removal of cyclodextrin at the end of the process, it is obtained GM1 with a titer of at least 95%. The present invention concerns also the intermediate complex that it is being formed between the hereabove said monosialoganglioside and alfa-cyclodextrin.

REFERENCES:
patent: 4868291 (1989-09-01), Yokoyama et al.
Carbohydrate Research, vol. 179, 1988, pp. 393-410, Elsevier Science Publishers B.V., Amsterdam et al, "Synthesis and characterization of lyso-GM3 (II3Neu5Ac lactosyl sphingosine), de-N-acetyl-GM3 (II3NeuNH2 lactosyl cer), and related compounds".
Biochem. J., vol. 88, 1963, pp. 373-383; D. B. Gammack: "Physicochemical properties of ox-brain gangliosides".

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