Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1985-06-06
1987-07-21
Hazel, Blondel
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
424 85, 435 68, C07K 1526, A61K 4502, C12P 2100
Patent
active
046819312
ABSTRACT:
The invention relates to a process for the isolation and purification of .alpha.-interferons generated by plasmids from bacterial cultures which have been modified by genetic engineering, and of .alpha.-interferons from culture supernatants of induced mammalian cells, which comprises partition of appropriate crude substances containing interferon between an aqueous urea solution, which contains a surfactant, and a mixture of n-butanol and glacial acetic acid which contains water, and isolation of the purified .alpha.-interferons from the upper phase.
REFERENCES:
patent: 4343735 (1982-08-01), Menge et al.
patent: 4450103 (1984-05-01), Konrad et al.
patent: 4462940 (1984-07-01), Hanisch et al.
L. S. Lin, Characterization of the Heterogeneous Molecules of Human Interferons: Differences in the Cross-Species Antiviral Activities of Various Molecular Populations in Human Leukocyte Interferons, J. General Virology, vol. 39, pp. 125-130, 1978.
Ludwig Jurgen
Obermeier Rainer
Salomon Ingeborg
Hazel Blondel
Hoechst Aktiengesellschaft
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