Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Reexamination Certificate
2007-03-13
2007-03-13
Campell, Bruce R. (Department: 1645)
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
C424S093100, C424S093200, C424S093400, C424S241100, C424S282100, C435S041000, C435S069100, C435S070100, C435S071100, C435S216000, C435S243000, C435S252100, C435S252300, C435S252330, C435S320100
Reexamination Certificate
active
10746046
ABSTRACT:
An improved process for the production of streptokinase using a genetically engineered strain ofEscherichia coliwhich overproduces streptokinase intracellularly and more particularly, the overall process disclosed herein, concerns with an improvement in the fermentative production of streptokinase using an optimized growth medium mainly comprised of simple salts and trace-elements; thus, in principal, the present process constitutes an improved and more economical means for the production of streptokinase which may be useful in thrombolytic therapy.
REFERENCES:
patent: 5187098 (1993-02-01), Malke et al.
Dao et al. 1985. Appl. Environ. Microbio. vol. 49(1): 115-119.
Dikshit Kanak Lata
Rajamohan Govindan
Ramandeep Ramandeep
Vyas Vinay Venkatrao
Campell Bruce R.
Council of Scientific & Industrial Research
Hines J.
Nixon & Peabody LLP
Studebaker Donald R.
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