Process for the in vivo recombination of DNA sequences having mi

Details Process for the in vivo recombination of DNA sequences having mi Process for the in vivo recombination of DNA sequences having mi

1994-04-25

1999-06-15

Ketter, James

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4351723, C12Q 168

Patent

active

059121190

ABSTRACT:
The present invention relates to a process of recombination in vivo of partially homologous DNA sequences having up to 30% of base mismatches. According to its essential characteristic, said sequences are placed together in cells or an organism of which the enzymatic mismatch repair system is defective or has been transitorily inactivated by saturation for the time to obtain recombination between said DNA sequences or in using mutants which increase the intergeneric recombination.

REFERENCES:
Triaby et al., J. Bact., vol. 121, 1975, pp. 608-618.
Cummins et al., Gene, vol. 14, 1981, pp. 263-278.
Smithies et al., Nature, vol. 317, 1985, pp. 230-234.
Sanderson et al., Escherichia coli and Salmonella typhimurium, 2.sup.nd ed., 1987, pp. 1138-1144.
Cleaver, Cell, vol. 76, 1994, pp. 1-4.
Jeyaprakash et al., Mut. Res., vol. 325, 1994, pp.21-29.

Affiliated with

Also associated with

Rating

Process for the in vivo recombination of DNA sequences having mi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the in vivo recombination of DNA sequences having mi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the in vivo recombination of DNA sequences having mi will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-401783