Process for the improvement of antibiotic production by in vivo

Details Process for the improvement of antibiotic production by in vivo Process for the improvement of antibiotic production by in vivo

1984-05-16

1988-03-08

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

4351722, 435253, 435886, 935 90, C12P 1948, C12N 1500, C12N 120, C12R 1465

Patent

active

047299517

ABSTRACT:
A process for the production of aminoglycoside antibiotics using fused protoplasts derived from streptomyces. The cells are precultured in a medium containing sucrose, calcium and magnesium salts. Protoplasts are formed and then fused. The fused protoplasts are regenerate and antibiotic producing ability is screened for. The regenerate cells produced an antibiotic complex of modified composition or demonstrated increased or reduced antibiotic productivity compared to the fusion partners.

REFERENCES:
patent: 4159226 (1979-06-01), Baltz
Ochi, K. Journal of Bacteriology, 150 (2): 592-597, 1982.
Hopwood, D. A. Ann. Rev Microbiol 35: 237-72, 1981.

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