Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1991-06-26
1993-03-09
Brown, Johnnie R.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435 46, 435100, 536 71, C12P 1904
Patent
active
051926717
ABSTRACT:
Avermectin compounds are glycosylated the 4' and 4"-positions by adding the avermectin compounds to the fermentation medium of Saccharapolyspora erythrea. The outer oleandrose sugar group of the avermectin compound is glycosylated with a glycosyl moiety, specifically a glucose group. In addition, other changes are effected in the avermectin moiety such as selective hydroxylation, epimerization at the 2-carbon and migration of the .DELTA. 3-double bond to a .DELTA. 2-position.
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Arison Byron H.
Doherty Patrick J.
Schulman Marvin D.
Brown Johnnie R.
DiPrima Joseph F.
Merck & Co. , Inc.
Rose David L.
Webber Pamela S.
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