Process for the glycosylation of avermectin agylcones

Details Process for the glycosylation of avermectin agylcones Process for the glycosylation of avermectin agylcones

1991-09-19

1993-02-23

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 75, 4352535, 435886, 514 30, 536 71, C12P 1962, C12P 1960, C12R 1465

Patent

active

051889447

ABSTRACT:
Avermectin aglycones are glycosylated by fermentation in a medium of a non-producing mutant of Streptomyces avermitilis MA-6078. The glycosylation produces the monosaccharide and disaccharide derivatives while leaving the remainder of the molecule intact. The microorganism glycosylates with the .alpha.-L-oleandrose moiety.

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Streicher, S. L., et al., Cloning Genes for Avermectin Biosynthesis in Streptomyces avermitilis Amer. Soc. for Microbiol. pp. 44-52.

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