Process for the fractionation of polymers

Details Process for the fractionation of polymers Process for the fractionation of polymers

2005-12-20

2005-12-20

Therkorn, Ernest G. (Department: 1723)

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

C210S634000, C568S621000, C568S624000

Reexamination Certificate

active

06977045

ABSTRACT:
A process for the purification or fractionation of aqueous soluble polymers using an aqueous two-phase system is described. The concentrations of the polymer to be fractionated and of an aqueous soluble salt, and the temperature of the aqueous fractionation medium are adjusted so that two phases form, the lower molecular weight polymer molecules partition into the high salt concentration phase, and the higher molecular weight polymer molecules partition into the low salt concentration phase. The resulting high molecular weight polymers are characterized by a higher average molecular weight and a narrower molecular weight distribution and decreased unsaturation than the unfractionated polymers. After being subjected to the fractionation process, polyol polymers that form hydrogels in aqueous solution exhibited higher viscosities and a liquid to gel transition over a narrower temperature range than the unfractionated polyol polymers.

REFERENCES:
patent: 5028336 (1991-07-01), Bartels et al.
patent: 5116508 (1992-05-01), Kumar et al.
patent: 5523492 (1996-06-01), Emanuele et al.
patent: 5567859 (1996-10-01), Emanuele et al.
patent: 5605687 (1997-02-01), Lee
patent: 5691387 (1997-11-01), Emanuele et al.
patent: 5696298 (1997-12-01), Emanuele et al.
patent: 5800711 (1998-09-01), Reeve et al.
patent: 5990241 (1999-11-01), Emanuele et al.
patent: RE36665 (2000-04-01), Emanuele et al.
patent: 6761824 (2004-07-01), Reeve et al.
patent: 9216484 (1992-10-01), None
patent: 9829459 (1998-07-01), None
patent: 9920683 (1999-04-01), None
patent: 0126692 (2000-04-01), None
patent: 0140321 (2001-06-01), None
Englard, S., et al; (1990) Chapter 22: Precipitation Techniques.Methods in Enzymology182, 285-300.
Hatti-Kaul, Rajni. (2000) Aqueous Two-Phase Systems, Methods and Protocols Humana Press.
King, T.P (1972) Separation of Proteins by Ammonium Sulfate Gradient Solubilization.Biochemistry, 11 (3), 367-371.
Kula, M.R., et al (1999) “Protein Purification, Aqueous Liquid Extraction”, 2179-2191, inEncyclopedia of Bioprocess Technology: Fermentation, Biocatalysis, and Bioseparation, eds. Flickinger and Drew, John Wiley & Sons, Inc.
Reeve, LE. (1997) “The Poloxamers: Their Chemistry and Medical Applications”, 231-249; inHandbook of Biodegradable Polymers, eds. Domb, Kost and Wiseman, Harwood Academic Publishers.
Rodriguez. F. (1989) “Principles of Polymer Systems” (3rdedition), Hemisphere Publishing Corp. p. 154.
Tarli, P., et al (1974) Human Pituitary Growth Hormone: Solubility in Ammonium Sulfate Solutions.Archives Biochemistry and Biophysics, 161, 696-697.

Affiliated with

Also associated with

Rating

Process for the fractionation of polymers does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the fractionation of polymers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the fractionation of polymers will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3472068