Process for the formation of human-human hybridoma

Details Process for the formation of human-human hybridoma Process for the formation of human-human hybridoma

1987-03-30

1990-04-10

Warren, Charles F.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 7021, 4351722, 43524026, 435948, 530387, 530809, 935 90, 935100, C12N 500, A61K 39395

Patent

active

049160729

ABSTRACT:
A human-human hybridoma is formed by subjecting a transformed human cell to a proliferaton inhibitory treatment and then fusing the thus-treated human cell with a human antibody producing cell. A desired clone may be selected from the resultant fused cells by using an anti-HLA antibody.

REFERENCES:
patent: 4675295 (1987-06-01), Osawa et al.
Carson et al., Advances in Immunol. 38:275, 296-7, (1986).
Kozbor et al.(a), PNAS 79:6651-55 (1982).
Kozbor et al.(b), Immunology Today 4(3):72-79 (1983).
Asada et al., Cell. Immunol. 77(1):150-60 (1983).
Higuchi et al., Cell. Immunol. 78(2):257-65 (1983).

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