Process for the fermentative preparation of L-amino acids from .

Details Process for the fermentative preparation of L-amino acids from . Process for the fermentative preparation of L-amino acids from .

1986-09-18

1991-10-01

Warden, Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435108, 435115, 435116, 435193, 435832, 435833, 435834, 435835, 435836, 435837, 435838, 435839, C12P 1306

Patent

active

050533282

ABSTRACT:
The preparation of an L-amino acid, particularly valine, leucine, isoleucine, alanine and phenylalanine, from the corresponding .alpha.-keto carboxylic acid by bacterial fermentation in the presence of ammonium ions is carried out with the aid of thermophilic Bacillus strains at temperatures above 45.degree. C., in particular above 60.degree. C. Bacillus strains DSM 406, 452, 461, 42, 463, 465 and 466 are particularly suitable for this purpose. The greater solubility of the amino acid at the elevated fermentation temperature permits the separation out of the amino acid from the reaction mixture simply by cooling, whereafter the depleted reaction mixture can be pumped back into the fermenter. Especially favorable yields are achieved by supplying oxygen to the fermenter to an amount of less than about 20% dissolved oxygen.

REFERENCES:
patent: 4119493 (1978-10-01), Isowa et al.
Chemical Abstract, 100:13728w, "Reaction Technology of the Enzymically Catalyzed Production of L-Alanine", (1983), Fiolitakis et al.
Chemical Abstract; 98:51907g, "Multienzyme Systems in Membrane Reactors", (1982), Wandrey et al.
Chemical Abstract, 85:174086c, "Regulatory Control and Function of Alanine Dehydrogenase from a Thermophilic Bacillus", Epstein (1976).
R. E. Buchanan et al., "Bergey's Manual of Determinative Bacteriology", (1975).
K. Yamada et al., "The Microbial Production of Amino Acids", (1972).
Chemical Abstracts, 104:65540m, "Screening of Thermostable Leucine and Alanine Dehydrogenases in Thermophillic Bacillus Strains", (1985).
Matsumoto et al., "Studies on DL-Alanine Formation by Thermophilic Bacteria", Agr. Biol. Chem., vol. 31, No. 12, pp. 1381-1388, 1967.

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