Process for the fermentation production of ergoline derivatives

Details Process for the fermentation production of ergoline derivatives Process for the fermentation production of ergoline derivatives

1976-11-08

1978-04-25

Tanenholtz, Alvin E.

Textiles: fiber preparation

C12D 1302

Patent

active

040861414

ABSTRACT:
Ergoline derivatives including alkaloids and 9,10-dihydroalkaloids of the ergotoxine group and including ergometrine are made by forming a submerged culture under aerobic conditions by inoculation of an aqueous medium containing a carbon source, an organic or inorganic nitrogen source or both of these sources, and nutrient salts, the inoculum being spores obtained from a strain of Claviceps purpurea (Fr.) Tul. deposited under number IMET PA 130, and then, after completion of the cultivation, extracting the formed alkaloids from the culture and, if necessary, 9,10-dihydrogenating the extracted alkaloids, and converting the alkaloids into pharmaceutically acceptable acid addition salts.

REFERENCES:
patent: 2809920 (1957-10-01), Stoll et al.
patent: 3110651 (1963-11-01), Kybal et al.
patent: 3276972 (1966-10-01), Amici et al.
patent: 3658653 (1972-04-01), Amici et al.

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