Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from valeriana
Reexamination Certificate
2005-07-05
2005-07-05
Lilling, Herbert J. (Department: 1651)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Containing or obtained from valeriana
C424S773000
Reexamination Certificate
active
06913770
ABSTRACT:
A process for preparing a pharmaceutically-active extract of the root of a plant of the family Valerianacae, specifically,Valeriana officinalisL., is described. This process comprises the steps of adding the roots to an alcoholic extraction solvent to form a mixture, wherein the alcoholic extraction solvent comprises between approximately 50% to approximately 100% (v/v) in a remainder of water, and heating the mixture to a temperature of between approximately 70° C. to approximately 80° C. for a period of at least approximately two hours. By this process valerenic acid is obtained in the extract, and the extract has a content of valepotriates and valepotriate degradation products or derivatives that is substantially reduced with respect to the content of valepotriates in the roots, and has a content of valerenic acids that is not substantially reduced with respect to the content of valerenic acids in the roots. Also preferably, the content of volatile oils in the extract is also not substantially with respect to the content of volatile oils in the roots. A pharmaceutically-active extract of the root of a plant of the family Valerianaceae is also described. This extract is obtained by a process comprising the steps of adding the roots to an alcoholic extraction solvent to form a mixture, wherein the alcoholic extraction solvent comprises between approximately 50% (v/v) to approximately 100% (v/v) in a remainder of water, and heating the mixture to a temperature of between approximately 70° C. to approximately 80° C. for a period of at least approximately two hours. This extract may be used in the formulation of an ingestible form, preferably exhibiting sedative and/or muscle relaxant, and/or anxiolytic activity.
REFERENCES:
patent: 3420935 (1969-01-01), Majnarich
patent: 3422090 (1969-01-01), Thies et al.
patent: 3869476 (1975-03-01), Thies et al.
patent: 4263285 (1981-04-01), Debate et al.
patent: 4313930 (1982-02-01), Wischniewski et al.
patent: 4382961 (1983-05-01), Nedeczky nee Gardy et al.
patent: 4946682 (1990-08-01), Stirnadel et al.
patent: 4981688 (1991-01-01), Ayroles et al.
patent: 5211948 (1993-05-01), Cerise et al.
patent: 5322688 (1994-06-01), Schwabe
patent: 5714150 (1998-02-01), Nachman
patent: 6383526 (2002-05-01), Andrews et al.
patent: 0631624 (1982-08-01), None
patent: 03112737 (1982-10-01), None
patent: 3112737 (1982-10-01), None
patent: WO 09/13054 (1998-04-01), None
Chemical Abstracts; Pharmaceutical Chemistry 26:3873 (1932)-Abstract of Traberg, J.E.,Dansk. Tids. Farm.6:17-19 (1932).
Botaniclas International Online Catalog, http://www. Botanicalsintl. com/.
Nutrition Science New, Sep. 1998; “Standardizing Extracts: S. Dental;Boon or Bane”; “Keep Natural products Natural,” C. Cabrera.
“USP Finds Valerian Evidence Lacking”, http//www.usp.org/.
Gardening, “Welcome to the herbhouse,” http//pages.prodigy.com/gardenshop.
Box R. et al., Phytochem, Anal., vol. 7 143-151 (1996).
Canyon Herbs and Acupuncture, “Making an Herbal Extract,” Jul. 9, 2000.
K.O. Hiller et al. (1996) Neuropharmacological studies on ethanol extracts of valeriana officinalis L.: Behavioural and anticonvulsant properties. Phytotherapy Research. 10:(2)145-151.
Deutsches Arzneibuch DAB 7 listing of “Tinctura Valerianae” copy, reproduction and translation. German Pharm. 7thED (1967).
Andrews Michael J.
Basu Amaresh
Ancile Pharmaceuticals
Knobbe Martens Olson & Bear LLP
Lilling Herbert J.
LandOfFree
Process for the extraction of valerian root does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the extraction of valerian root, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the extraction of valerian root will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3424388