Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
2000-01-14
2001-04-10
Page, Thurman K. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C424S195110, C424S401000, C514S844000, C514S847000
Reexamination Certificate
active
06214361
ABSTRACT:
The present invention relates to a process for the extraction of an active principle of vegetable origin, in this instance from de-oiled tournesol or sunflower seeds, to counter cutaneous aging.
The invention also covers the active principle obtained and the corresponding compositions.
It is known that the reaction of protein glycolation also called the Maillard reaction, is involved in the process of molecular and tissue aging.
This glycolation reaction is in fact a group of successive reactions. In the absence of suitable enzymes, a reaction takes place between a primary free amine function and a reducing function of a reducing sugar such as glucose, to produce glycolated protein. The latter can then undergo a glyco-oxidation reaction. These reactions lead to very stable end compounds rich in double bonds which when broken give irreversible cross-linkages.
One can counter accelerated aging, particularly of the skin, by limiting or retarding this glycolation phenomenon because the glycolic proteins thus cross-linked lose their biological functionality, the tissues rigidify and harden.
Moreover, there exists another well-known factor which also contributes to cutaneous aging, namely free radicals.
Thus, the glycolated proteins react with oxygen and form free radicals such as super oxides. These compounds can initiate the degradation of certain proteins and/or alter the membrane structures. Similarly, the accumulation of free radicals in tissue also catalyzes the glycolation reaction of the proteins which lose their biological properties.
The glycolation reaction can also modify the properties of the macromolecules that are constituents of the extra-cellular matrix, such as the proteoglycanes, the glycoproteins, elastins and collagens.
The formation of irreversible cross-linkages renders the fibrous collagen molecules for example more fragile and the terminal compounds of the glycolation reaction also modify the synthesis of the macroproteins of the extra-cellular matrix. These compounds modify the metabolism of the fibroblasts.
The glycolic proteins also become resistant to the action of proteases, the collagen resists the action of collagenase and the renewal of the collagen is not ensured, which leads to broken and altered tissues.
The active principle according to the invention has for its object to counter the undesirable glycolation actions by two actions:
a powerful anti-oxidant and anti-radical action, by the presence of phenolic acids which trap the free radicals and limit the oxidation reactions, and
occupation by glycopeptides of the protein sites involved in specific glucose/protein bonds, preventing the bridges so as to abort the glycolation reaction.
The present invention covers a process for the extraction of an active principle from de-oiled sunflower seeds as well as the active principle obtained. The invention also covers the obtained compositions.
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XP-002147748, “Production of protein isolates from extracted sunflower grits”,Acta Alimentaria,AN 85(03):G0017 (1985).
XP-002147749, “Optimization of the enzymic treatment during aqueous oil extraction from sunflower seeds”,Food Chemistry,AN 1998:287902 (1998).
XP-002147750, “Removal of chlorogenic acid from sunflower seeds and meals”, AN 79(09):G0786 (1979).
Page Thurman K.
S.A. Societe Industrielle Limousine d'Application Biologiqu
Tran S.
Young & Thompson
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