Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1982-06-28
1984-10-09
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
424 9, A61K 4300, A61K 4900
Patent
active
044761066
ABSTRACT:
A process for the preparation of a fatty acid tagged with radioactive iodine, wherein a brominated or iodized fatty acid is reacted, preferably in the omega position, with radioactive iodide in the dry state or with an aqueous solution of radioactive iodide, in the presence of vehicling iodide, to exchange the bromine or iodine of such fatty acid for radioactive iodine.
Application to use as radio-pharmaceutical products for studying cardiac metabolism troubles in human beings by scintigraphy.
REFERENCES:
patent: 4290965 (1981-09-01), Stocklin et al.
patent: 4323547 (1982-04-01), Knust et al.
Van Der Wall, Chem. Abstracts, 96, (1982), #208308w.
Freundlieb et al., Chem. Abstracts, 91, (1979), #188824c, 95, (1981), #78082j.
Machulla et al., Chem. Abstracts, 95, (1981), #80498t.
Knapp et al., J. Nucl. Med., 22, (1981), 988-993.
Journal of Nuclear Medicine, vol. 16, No. 1, Jan. 1975, G. D. Robinson et al., "Radioiodinated Fatty Acids for Heart Imaging: Iodine Monochloride Addition Compared with Iodine Replacement Labeling", pp. 17-21.
Bardy Andre
Comet Michel
Coornaert Sabine
Mathieu Jean-Paul
Riche Francoise
Commissariat a l''Energie Atomique
Nucker Christine M.
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