Process for the enzymatic synthesis of nucleosides

Details Process for the enzymatic synthesis of nucleosides Process for the enzymatic synthesis of nucleosides

1989-04-06

1991-12-24

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 88, 435 89, 435194, C12P 1938, C12P 1940, C12P 1930, C12N 912

Patent

active

050752251

ABSTRACT:
A process for synthesizing nucleosides is disclosed. The process includes the reaction of an alkylated nucleoside (such as 7-methylguanosine or 7-methylinosine) with a heterocyclic base (such as adenine, 3-deazaadenine or 1,2,4-triazole-3-carboxamide) in the presence of a nucleoside-forming enzyme to form a nucleoside that includes a glycosyl component, donate by the alkylated nucleoside, bonded to the heterocyclic base.

REFERENCES:
patent: 4347315 (1982-08-01), Krenitsky et al.
patent: 4381344 (1983-04-01), Rideout et al.
patent: 4594320 (1986-06-01), Fujishima
patent: 4594321 (1986-06-01), Fujishima
Krenitsky, et al., J. Med. Chem., 1986, vol. 29, pp. 138-143.
Krenitsky, et al., Carbohydrate Research, 1981, vol. 97, pp. 139-146.
Krenitsky et al., Biochemistry, 1981, vol. 20, pp. 3615-3621.
Krenitsky, et al., J. Med. Chem., 1982, vol. 25, pp. 32-35.
Rideout, et al., J. Med. Chem., 1982, vol. 25, pp. 1040-1044.
Utagawa, et al., Agric. Biol. Chem., 1986, vol. 50(1), pp. 121-126.
Jones, et al., J. Am. Chem., 1963, vol. 85, pp. 193-201.
Kulikowska, et al., Biochem. Biophys. Acta., 1986, vol. 874, pp. 355-363.
Stoeckler, et al., Fed. Proc. Fed. Am. Soc. Exp. Biol., 1986, vol. 45, pp. 2773-2778.
Witkowski et al., J. Med. Chem., 1972, vol. 15 (11), pp. 1150-1154.
Rousseau, et al., Biochemistry, 1966, vol. 5, pp. 756-760.
Stoltzfus, et al., J. Virol., 1981, vol. 38, pp. 173-183.
Oivanen, et al., J. Tet., 1987, vol. 43, pp. 1133-1140.
Ryba, et al., J. Chromatography, 1981, vol. 211, pp. 337-346.
Tener, et al., J. Chem. Soc., 1957, vol. 79, pp. 441-443.
Enzyme Nomenclature, Academic Press, 1984.
Hupe, et al., Ann. Reports in Medicinal Chemistry, Bailey, Ed., Academic Press, New York, 1986, vol. 21, Ch. 23.
Mansuri, et al., Ann. Reports in Medicinal Chemistry, Bailey, Ed., Academic Press, New York, 1987, vol. 22, Ch. 15.
Mansuri, et al., Ann. Reports in Medicinal Chemistry, Allen, Ed., Academic Press, New York, 1988, vol. 23, Ch. 17.
Ezzell, Nature, 1987, vol. 326, p. 430.
DeClerg, Trends in Pharmacol. Sci., 1987, vol. 8, pp. 339-345.
Lerch, Antiviral Res., 1987, vol. 7, pp. 257-270.
Vanek, et al., J. Coll. Czech. Chem. Commun., 1984, vol. 49, pp. 2492-2495.
Sidewall, et al., Science, 1972, vol. 177, pp. 705-706.
Utagawa, et al., Agric. Biol. Chem., 1985, vol. 49, p. 3229.
Nucleoside Analogues; Chemistry, Biology and Medicinal Applications, Walker, et al., Eds., NATO Advanced Study Institutes Seires, Plenum, New York, 1979, vol. 26.
Suhadolnik, Nucleoside Antibiotics, J. Wiley, New York, 1970.
Suhadolnik, Nucleosides as Biological Probes, J. Wiley, New York, 1979.
Robbins, et al., Can. J. Chem., 1973, vol. 51, p. 3161.
Mizuno, et al., Chem. Pharm. Bull., 1964, vol. 12, p. 866.

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