Process for the enzymatic synthesis of 2-deoxy-.beta.-D-galactos

Details Process for the enzymatic synthesis of 2-deoxy-.beta.-D-galactos Process for the enzymatic synthesis of 2-deoxy-.beta.-D-galactos

1992-04-07

1993-11-23

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 74, 435 75, 435 84, 435 85, 435100, 435193, C12P 1918, C12P 1912, C12P 1928, C12N 910

Patent

active

052643522

ABSTRACT:
The invention relates to a process for the enzymatic synthesis of 2-deoxy-.beta.-D-galactosides. The enzyme galactosyltransferase is able to catalyze the transfer of 2-deoxygalactose residues from the donor substrate uridine 5'-diphospho-2-deoxy-D-galactose to N-acetylglucosamine or aspartyl-N-acetylglucosamine or, in the presence of lactose, to terminal glucose.

REFERENCES:
Joachim Thiem et al., "Galactosyltransferase-catalyzed synthesis of 2'-N-acetyllactosamine", Angewandte Chemie. International Edition. 1-8 Bd. 30 No. 9, 1163-1164 Sep. 1991.
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Palcic et al., "Flexibility in the Donor Substrate Specificity of .beta.1, 4-Galactosyltransferase: Application in the Synthesis of Complex Carbohydrates," Glycobiology vol. 1, No. 2, pp. 205-209 (1991).

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