Process for the enzymatic separation of the optical isomers of r

Details Process for the enzymatic separation of the optical isomers of r Process for the enzymatic separation of the optical isomers of r

1987-12-24

1990-06-12

Rosen, Sam

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435117, 435120, C12P 4100

Patent

active

049332902

ABSTRACT:
There is disclosed a process for the biotechnological resolution, by enzymatic esterification of the corresponding racemic mixture of the S(+) and R(-) optical isomers of the oxazolidinonic compounds having formula (I): ##STR1## wherein R represents a, linear or branched, C.sub.1 -C.sub.8 alkyl group, which process is characterized in that, the racemic 3-alkyl-5-hydroxymethyl-oxazolidin-2-one derivative of formula (I) is reacted with an esterifying compound, selected from esters having formula (III): ##STR2## wherein R represents a, linear or branched, C.sub.1 -C.sub.10 alkyl or alkenyl group and R" represents a linear or branched, C.sub.1 -C.sub.4 alkyl, alkenyl group, a haloalkyl (chlorine, bromine) group or a diacyl glycerolic group or from acids having formula (IV):

REFERENCES:
patent: 4588694 (1986-05-01), Hamaguchi et al.
Hamaguchi et al.--Chem. Abst. vol. 104 (1986) p. 166940x.
Funda et al.--Chem. Abst. vol. 100 (1984) p. 81857t.

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