Process for the enzymatic separation of enantiomers of

Details Process for the enzymatic separation of enantiomers of Process for the enzymatic separation of enantiomers of

1997-09-17

1999-01-19

Saucier, Sandra E.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435921, C12P 4100

Patent

active

058613048

ABSTRACT:
!heptane-7-carboxylic acid esters using lipase from candida.
Compounds of the formula I ##STR1## in which R.sup.1 has the meanings mentioned, may be obtained in isomerically pure form from enantiomer mixtures or racemic mixtures by reacting the compound of the formula I in the presence of a lipase or esterase from porcine liver, porcine pancreas, bovine pancreas or from microorganisms such as Candida, Pseudomonas, Mucor, Rhizopus and Aspergillus, or proteases from Bacillus in the presence of water and, if desired, a cosolvent and separating from one another the esters and acids present in the solution obtained.

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Cervinka et al., "Absolute Configuration of Acid", Collection Czechoslovak Chemical Commun., 48:3565-3566 (1983).
Bartmann et al., "Synthese eines biologisch aktiven Analogons des Prostaglandins E.sub.2 (Racemat und reine Enantiomere)", Liebigs Ann. Chem., pp. 321-326 (1987).
Hofle et al., "4-Dialkylaminopyridine als hochwirksame
Geckeler et al., "Synthese von Aminoaure-alkenylestern", Chem. Ber., 107:1271-1274 (1974).
Haslam, "Recent Developments in Methods for the Esterification and Protection of the Carboxyl Group", Tetrahedron Report, 36(93) :2409-2433 (1980).
Stanek et al., 110:231177u, abstract of CS 240,862 (1988).

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