Process for the enzymatic resolution of 2-amino-4-methyl-phosphi

Details Process for the enzymatic resolution of 2-amino-4-methyl-phosphi Process for the enzymatic resolution of 2-amino-4-methyl-phosphi

1995-05-25

1998-05-26

Kumar, Shailendra

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558170, 558172, 435280, C07F 932

Patent

active

057568006

ABSTRACT:
Process for the enzymatic resolution of 2-amino-4-methylphosphinobutyric acid derivatives.
L-PTC (L-phosphinothricin, L-2-amino-4-methylphosphinobutyric acid) is the active herbicidal component of D,L-PTC and can be obtained according to the invention when D,L-PTC derivatives which are N-acylated and esterified on the phosphinic acid group as well as optionally esterified or amidated on the carboxylic group, are treated with a hydrolytically active enzyme in an aqueous or aqueous-organic medium, in which process the L-PTC derivatives are selectively hydrolyzed on the N-acyl group or the modified carboxyl group, the resulting product mixture is resolved, and the desired L-PTC derivative is hydrolyzed to give the L-PTC and isolated by customary methods.

REFERENCES:
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patent: 5051525 (1991-09-01), Wilms
Plaskie et al., Substrate Specificity of Pencillin Acylase of E. coli, The Journal of Antibiotics, vol. XXXI No. 8, pp. 783, 786 and 787, Aug. 1978.
Natchev, Bull. Chem. Soc. Japan, pp. 3699-3704, and 3705-3709, 1988.
Natchev, J. Chem. Soc. Perk Trans I, pp. 125-131, Jan. 1989.

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