Process for the enzymatic resolution of 2-amino-4-methyl-phosphi

Details Process for the enzymatic resolution of 2-amino-4-methyl-phosphi Process for the enzymatic resolution of 2-amino-4-methyl-phosphi

1996-01-23

1998-05-26

Kumar, Shailendra

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435131, 435106, 435874, 435876, C12P 4100, C12P 1304, C07C23116

Patent

active

057563462

ABSTRACT:
L-PTC (L-phosphinothricin, L-2-amino-4-methylphosphino-butyric acid) is the active herbicidal component of D,L-PTC and can be obtained according to the invention when D,L-PTC derivatives which are N-acylated and esterified on the phosphinic acid group as well as optionally esterified or amidated on the carboxylic group, are treated with a hydrolytically active enzyme in an aqueous or aqueous-organic medium, in which process the L-PTC derivatives are selectively hydrolyzed on the N-acyl group or the modified carboxyl group, the resulting product mixture is resolved, and the desired L-PTC derivative is hydrolyzed to give the L-PTC and isolated by customary methods.

REFERENCES:
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patent: 4859602 (1989-08-01), Zimmermann et al.
patent: 5010012 (1991-04-01), Wullbrandt et al.
Plaskie et al., Substrate Specificity of Penicillin Acylase of E. coli, The Journal of Antibiotics, vol. XXXI No. 8, pp. 783, 786 and 787, Aug. 1978.
M. Dixon, E. C. Webb, "Enzymes" 2d Ed., Longmans, Green & Co., Ltd., London 1964, pp. 346-352).

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