Process for the enzymatic resolution of 2-amino-4-methyl-phosphi

Details Process for the enzymatic resolution of 2-amino-4-methyl-phosphi Process for the enzymatic resolution of 2-amino-4-methyl-phosphi

1998-01-05

1999-03-09

Redding, David A.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435106, 435131, 562104, C12P 4100

Patent

active

058799303

ABSTRACT:
L-PTC (L-phosphinothricin, L-2-amino-4-methylphosphino-butyric acid) is the active herbicidal component of D,L-PTC and can be obtained according to the invention when D,L-PTC derivatives which are N-acylated and esterified on the phosphinic acid group as well as optionally esterified or amidated on the carboxylic group, are treated with a hydrolytically active enzyme in an aqueous or aqueous-organic medium, in which process the L-PTC derivatives are selectively hydrolyzed on the N-acyl group or the modified carboxyl group, the resulting product mixture is resolved, and the desired L-PTC derivative is hydrolyzed to give the L-PTC and isolated by customary methods.

REFERENCES:
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patent: 4389489 (1983-06-01), Preiss et al.
patent: 4859602 (1989-08-01), Zimmermann et al.
patent: 5010012 (1991-04-01), Wallbrandt et al.
M. Dixon, E.C. Webb, "Enzymes" 2d Ed., Longmans, Green & Co., Ltd., London 1964, pp. 346-352.
Plaskie et al., Substrate Specificity of Penicillin Acylase of E.coli, The Journal of Antibiotics, vol. XXXI No. 8, pp. 783, 786 and 787, Aug. 1978.

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