Process for the enzymatic production of ketones

Details Process for the enzymatic production of ketones Process for the enzymatic production of ketones

1988-07-22

1991-06-25

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435118, 435119, 435120, 435121, 435122, 435123, 435124, 435125, 435126, 435127, 435128, 435155, 435190, 435280, 435930, 435942, C07C125065, C07C10130, C12P 702, C12P 742

Patent

active

050266420

ABSTRACT:
In a process for the reduction of ketones, the keto compounds are enantioselectively reduced to give secondary alcohols by means of microorganisms. Keto compounds of the formula

REFERENCES:
"Synthesen der (3S,4S)-4-Amino-3-Hydroxy-6-Methylheptansaure und Einiger Derivate", Steulmann et al., Liebigs Ann. Chem. 1975, pp. 2245-2250.
"Yeast Reduction of Ethyl Acetoacetate: (S)-(+)-Ethyl 3-Hydroxybutanoate", Seeback et al., Organic Synthesis, 63, pp. 1-9 (1985).
"Stereochemical Control in Microbial Recution 4. Effect of Cultivation Conditions on the Recution of .beta.-Keto Esters by Methylotrophic Yeasts", Ushio et al., Tetrahedron Letters, vol. 27, No. 23, pp. 2657-2660 (1986).
"Substrate Modification as a Means of Enhancing the Enantioselectivity of Microbial Reductions of .beta.-Keto Esters. An (R)- or (S)-1,3,5-Trihydroxypentane Synthon", Brooks et al., Journal of Organic Chemistry, 1987, 52, pp. 192-196.
R. Scheffold, ed., Modern Synthetic Methods 1989, pp. 54-55, 106-107.

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