Process for the enzymatic preparation of enantiomer-enriched...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing alpha or beta amino acid or substituted amino acid...

Reexamination Certificate

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C435S197000, C435S198000, C435S280000

Reexamination Certificate

active

06987010

ABSTRACT:
The present invention relates to processes for the preparation of enantiomerically enriched β-amino acids. The invention also relates to advantageous esters of β-amino acids of the general formula (I)and to the use thereof in the enzymatic preparation of enantiomerically enriched β-amino acids.

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patent: 5552317 (1996-09-01), Houng et al.
patent: 6063615 (2000-05-01), Stürmer et al.
patent: 0 890 649 (1998-06-01), None
patent: WO 98/50575 (1998-11-01), None
patent: WO 01/16090 (2001-03-01), None
English Language Abstract for EP 0 890 649 A1, Reference AJ1 above.
Abdel-Magid, et al., “Chemical Process Synthesis of β-Amino Acids and Esters,”Current Medicinal Chemistry 6:955-970 (1999).
Boesch, et al., “An Expedient Method for Resolution of 3-Amino-3-(3′-Pyridyl)Propionic Acid and Related Compounds,”Organic Process Research&Development 5:23-27 (2001).
Faulconbridge, et al., “Preparation of Enantiomerically Enriched Aromatic β-Amino Acids Via Enzymatic Resolution,”Tetrahedron Lett. 41:2679-2681 (2000).
Juaristi, et al., “Recent Advances in the Enantioselective Synthesis of β-Amino Acids,”Current Medicinal Chemistry 6:983-1004 (1999).
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Sánchez, et al., “Candida antarcticaLipase Catalyzed Resolution of Ethyl (±)-3-Aminobutyrate,”Tetrahedron:Asymmetry 8:37-40 (1997).
Soloshonok, et al., “An Enzymatic Entry to Enantiopure β-Amino Acids,”Synlett:339-341 (May 1993).
Soloshonok, et al., “Biocatalytic Resolution of β-Fluoroalkyl-β-Amino Acids,”Tetrahedron:Asymmetry 5:1119-1126 (1994).
Soloshonok, et al., “Biocatalytic Approach to Enantiomerically Pure β-Amino Acids,”Tetrahedron:Asymmetry 7:1601-1610 (1995).
Database Crossfire/Beilstein 'Online! Beilstein Registry No. 2939300. Jun. 2, 1992, “3-Amino-3-phenyl-propionsäure-propylester” ZP002248822.

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