Process for the enzymatic preparation of 7-amino-cephalosporanic

Details Process for the enzymatic preparation of 7-amino-cephalosporanic Process for the enzymatic preparation of 7-amino-cephalosporanic

1992-07-14

1994-07-26

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-5-aza-bicyclo

435 47, 435170, 435832, 435834, 435874, C12P 3502, C12P 3500, C12P 104

Patent

active

053326636

ABSTRACT:
7-amino-cephalosporanic acids having the formula ##STR1## are obtained by submitting compounds having the following formula to enzymatic conversion: ##STR2## wherein R represents H, OH, O--CO--R", R" being an alkyl radical with from 1 to 4 carbon atoms, R.sup.1 represents a carboxylic group. The reaction is carried out in the presence of a microorganism selected from the Pseudomonas, Bacillus, Achromobacter genera, or in the presence of an enzyme, either free or immobilized, derived therefrom.

REFERENCES:
patent: 3239394 (1966-03-01), Walton
patent: 3304236 (1967-02-01), Nuesch et al.
patent: 3962036 (1976-06-01), Liersch et al.
patent: 4302541 (1981-11-01), Hirata et al.
patent: 4774179 (1988-09-01), Ichikawa et al.
Chemical Abstracts, Ichikawa et al, "Manufacture of cephalosporin C acyla", Sep. 28, 1987, vol. 107, No. 13, Abstract No. 114281a, p. 517.
Chemical Abstracts, Ichikawa et al, "Cephalosporin C Acylase manufacture by Pseudomonas species.", Sep. 28, 1987, vol. 107, No. 13, Abstract No. 114280z, p. 517.

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