Process for the enzymatic dispersal of Mycobacterium bovis - BCG

Details Process for the enzymatic dispersal of Mycobacterium bovis - BCG Process for the enzymatic dispersal of Mycobacterium bovis - BCG

1990-01-29

1992-02-25

Moezie, F. T.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

4352531, 424 92, 424 93D, C12P 950, C12N 120

Patent

active

050913085

ABSTRACT:
Mycobacterium bovis BCG suspensions are treated with a protease enzyme such as pronase, resulting in the production of suspensions having smaller aggregates and single cells. Such suspensions, when processed into vaccines, exhibit improved immunizing potential against cancer and would be expected to exhibit improved immunizing potential against tuberculosis.

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patent: 4777130 (1988-10-01), Maes
Abaas, Acta Pathol. Microbiol. Immunol. Scand. Seet B Microbiol, vol. 93(1), pp. 15-20 (1985).
Abaas et al., Acta Pathol. Microbiol. Immunol. Scand. Seet B Microbiol., vol. 91 (5) pp. 317-24 (1983).
Abaas et al., Scand. J. Dent. Res. 90(2) 109-116 (1982).
Abaas et al., Scand. J. Dent. Res. 89(5) pp. 366-373 (1981).
Hardham et al., Microbios. Letters, vol. 13, pp. 33-42.

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