Process for the enzymatic cleavage of 2-amino-4-methyl-phosphino

Details Process for the enzymatic cleavage of 2-amino-4-methyl-phosphino Process for the enzymatic cleavage of 2-amino-4-methyl-phosphino

1995-06-07

1997-04-08

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435106, C12P 4100, C12P 900, C12P 1304

Patent

active

056187289

ABSTRACT:
Process for the enzymatic separation of phosphinothricin derivatives, which comprises treating a mixture of D- and L-phosphinothricin derivatives of the formulae (I) and (II) ##STR1## with a hydrolytically active enzyme in an aqueous or aqueous-organic medium.

REFERENCES:
patent: 4389488 (1983-06-01), Grabley et al.
patent: 5051525 (1991-09-01), Willms et al.
patent: 5374736 (1994-12-01), Zeiss
Dixon, M. et al., Enzymes, Chapter VIII, "Enzyme Inhibitors" Pharma Biochemie u. Mikr., Longmans 2nd Ed. pp. 346-353.
Kruizinga, W.H. et al., "Synthesis of Optically Pure .alpha.-Alkylated .alpha.-Amino Acids and a Single-Step Method for Enantiomeric Excess Determination" J. Org. Chem. 1988, 53, 1826-1827.
Sasaki, M. et al., "Synthesis of Skeleton of Antitumor Quassinoid" Bull. Chem. Soc. Jpn, 61, 3587-3605, Oct. 1988.
The Chemical Science Society of Japan, Oct., 1988, pp. 3699-3704 by Ivan A. Natchev entitled "Organophosphorus Analogues and Derivatives of the Natural L-Amino Carboxylic Acids and Peptides. I. Enzymatic Synthesis of D-, DL-, and L-Phosphinothricin and Their Cyclic Analogues".

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