Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...
Reexamination Certificate
2006-11-14
2006-11-14
Marx, Irene (Department: 1651)
Chemistry: molecular biology and microbiology
Process of utilizing an enzyme or micro-organism to destroy...
Resolution of optical isomers or purification of organic...
C435S130000
Reexamination Certificate
active
07135328
ABSTRACT:
The invention relates to a process for the production of (R)- or (S)-8-chloro-6-hydroxyoctanoic acid alkyl esters of the general formula (R)-II or (S)-II,in which R means C1-4alkyl, from 8-chloro-6-oxo-octanoic acid alkyl esters of the general formula I,in which R has the above meaning.The desired enantiomers are produced biocatalytically in an enantioselective reduction, wherein as desired the strains Mucor racemosus are used for (S)-II compounds and Geotrichum candidum for (R)-II compounds.The resultant esters may, in known manner, be converted stereospecifically into (R)-α-lipoic acid.
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Gewald Rainer
Olbrich Matthias
Buchanan & Ingersoll & Rooney PC
Marx Irene
Viatris GmbH & Co. KG
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