Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...
Patent
1992-11-13
1994-05-10
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing heterocyclic carbon compound having only o, n, s,...
435280, 435822, C12P 1718
Patent
active
053106660
ABSTRACT:
A Rhodotorula rubra strain has been found which reduces pentoxifylline to 100% to give the S-alcohol. Moreover, other oxoalkylxanthine derivatives can also be converted into the corresponding S-alcohol. The microbiologically obtained S-(+)-enantiomers can then be converted stereoselectively into the respective R-(-)-enantiomers. The corresponding S-alcohols and the R-alcohols obtained by enantioselective inversion of configuration cause an increase in cerebral blood flow.
REFERENCES:
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ATCC Catalog of Fungi/Yeasts, p. 267 (1984).
Saucier et al., J. Biol. Chem 264: 6863-6869 (1989).
Smith et al., J. Chrom. 281: 281-287 (1983).
Davis et al., Appl. Env. Microbiology 48: 327-331 (1984).
Jones et al., Tetrahedron 42: 3351-3403 (1986).
Davis et al, Xenobiotica 12: 1001-1010 (1985).
Mitteilung, European Search Report, dated Jun. 17, 1992.
Aretz Werner
Furrer Harald
Gebert Ulrich
Hinze Heinz-Joachim
Hoechst Aktiengesellschaft
Robinson Douglas W.
Saucier S.
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