Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2003-08-01
2009-02-10
Sullivan, Daniel M (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C564S358000, C564S354000, C549S058000
Reexamination Certificate
active
07488833
ABSTRACT:
A process for the enantioselective preparation of amino alcohols of formula Iby enantioselective hydrogenation of amino ketones of the formula IIin the presence of a non-racemic catalyst. The catalyst is a transition-metal complex in which the transition metal is complexed to a chiral diphosphine ligand.
REFERENCES:
patent: 4330730 (1993-09-01), None
patent: WO 02/04401 (2002-01-01), None
patent: WO 02/055477 (2002-07-01), None
G. Helmchen et al.: “Houben-Weyl Methods of Organic Chemistry; Additional and Suppl. Vol. to the 4thEd. vol. E 21 D, Stereoselective Synthesis (pp. 3995-3997, Chapter 2.2.1.2.7)” Nov. 30, 1995, George Thieme Verlag, Stutgart—New York XP002262293, ISBN: 3-13-100114-3.
G. Helmchen et al.: “Houben-Weyl Methods of Organic Chemistry; Additional and Suppl. Vol. to the 4th Ed. vol. E 21 D, Stereoselective Synthesis (pp. 3955-3957, Chapter 2.2.1.2.7)” Nov. 30, 1995, George Thieme Verlag, Stutgart- New York XP02262293, ISBN: 3-13-100114-3.
Sakurba et al. “Efficient Asymmetric Hydrogenation of γ-Amino Ketone Hydrochloride Derivatives catalyzed by (2S,4S)-4-Dicyclohexylphosphino-2-diphenylphosphinomethyl-1(N-methylcarbamoyl)-pyrrolidine(MCCPM)-Rhodium Complex”, Synlett, Oct. 1992, p. 829.
Sakurba et al. “Efficient Asymmetric Hydrogenation of β- and γ-Amino Ketone Derivatives leading to practical Synthesis of Fluoxetine and Eprozinol”, Chemical Pharmaceutical Bulletin 1995, p. 748.
G. Helmchen et al.: Houben-Weyl Methods of Organic Chemistry; Additional and Suppl. vol. of the 4thEd. vol. E 21d, Stereoselective Synthesis (pp. 3955-3957 Chapter 2.3.1.2.7) Nov. 30, 1995.
M. Kitamura et al.: “Homogeneous Asymmetric Hydrogenation of Functionalized Ketones” J.Am. Chem. Soc., Bd. 110, 1998 (pp. 629-631).
Fabian Kai
Kralik Joachim
Mürmann Christoph
Schweickert Norbert
Cutliff Yate′ K
Merck Patent GmbH
Miller, White, Zelano & Branigan, P.C.
Sullivan Daniel M
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