Chemistry: electrical and wave energy – Processes and products
Patent
1984-09-12
1985-10-15
Niebling, John F.
Chemistry: electrical and wave energy
Processes and products
204 75, 204 78, C25B 300
Patent
active
045472718
ABSTRACT:
A process for electrochemically reducing 7-ketolithocholic acid to ursodeoxycholic acid is disclosed. The process may be conducted alone or in conjunction with a simultaneous electrochemical oxidation of chenodeoxycholic acid to 7-ketolithocholic acid. Solvents for the electrochemical reaction which promote stereoselectivity to ursodeoxycholic acid are also disclosed.
REFERENCES:
patent: 2356596 (1939-08-01), Kramil et al.
patent: 3140989 (1964-07-01), Kabasakalian et al.
patent: 3386900 (1968-06-01), Slager
patent: 3506549 (1970-04-01), Throop et al.
patent: 3720694 (1973-03-01), Junghans
patent: 3990956 (1976-11-01), Junghans
patent: 4050998 (1977-09-01), Junghans
patent: 4251332 (1981-02-01), Ginsburg et al.
Holman et al., Tetrahedron Letters, "The Stereoselective Cathodic Reduction of Exo-Cyclic Double Bonds", No. 16, 1967, pp. 1553-1556.
James P. Colman, et al., J. Chem. Soc., 1976, pp. 879-884, (J.C.S. Perkin II) "Electro-Organic Reactions, PVI, Stereoselective Cathodic Reduction of Unhindered Cyclic Ketones".
John W. Huffman et al., J. Org. Chem., vol. 48, No. 9, 1983, pp. 1474-1479, "Metal-Ammonia Reduction of Cycloalkanones, A Revised Mechanism".
Robert A. Benkeser, et al., J. of the Am. Chem. Soc., "The Selective Reduction of Aroatic Compounds to Dihydro or Tetrahydro Products by an Electrochemical Method", vol. 86, 1964, pp. 5272-5276.
Heinz W. Sternberg et al., J. Am. Chem. Soc., "by Electrolytic Generation of Solvated Electrons and Reduction of the Benzene Ring in Ethanol Containing Hexamethylphosphoramide", vol. 89, Jan. 1967, pp. 186-187.
Throop et al., J. Am. Chem. Soc., vol. 89, p. 4788, (1967).
Heinz W. Sternberg, et al., J. Am. Chem. Soc., vol. 15, Jul. 1969, pp. 4191-4194, "by Electrolytically Generated Electrons".
J. P. Coleman, et al., Chem. Communications, "Stereoselective Electrochemical Reduction of Cyclic Ketones", 1971, pp. 104-105.
Bharucha Kekhusroo R.
Slemon Clarke E.
Canada Packers Inc.
Niebling John F.
LandOfFree
Process for the electrochemical reduction of 7-ketolithocholic a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the electrochemical reduction of 7-ketolithocholic a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the electrochemical reduction of 7-ketolithocholic a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2431497