Process for the direct preparation of 5-alkoxy and 5-acyloxy...

Details Process for the direct preparation of 5-alkoxy and 5-acyloxy... Process for the direct preparation of 5-alkoxy and 5-acyloxy...

2005-03-29

2005-03-29

Wallenhorst, Maureen M. (Department: 1743)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C436S128000, C436S174000, C436S178000

Reexamination Certificate

active

06872829

ABSTRACT:
A convenient and efficient process for direct preparation of 5-alkoxy and 5-acyloxy analogues of camptothecins (anticancer compounds) and mappicine ketones (antiviral compounds) has been invented by treatment of the parent compounds with alcohols and acids respectively in the presence of ceric ammonium nitrate (CAN) at room temperature. The process is simple, economic and completed within a short period of time.

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Subrahmanyam, et al., “Novel C-Ring Analogues of 20(s)-captothecin. Part 3: Synthesis and Their In Vitro Cytotoxicity of A-, B- and C-ring Analogues”, Bioorganic & Medicinal Chemistry Letters, Oxford, GB, vol. 10, No. 4, Feb. 2000, pp. 369-371.

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