Process for the direct and regioselective functionalization in p

Details Process for the direct and regioselective functionalization in p Process for the direct and regioselective functionalization in p

1991-04-05

1992-02-18

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 39, C07D27920, C07D27930, C07D 4506

Patent

active

050896130

ABSTRACT:
Preparation of 2-alkylthio-phenothiazines by direct functionalization of phenothiazine by reaction of the phenothiazine, N-protected by an acryl group, with a sulfonating agent such as sulfuric acid, sulfuric anhydride, chlorosulfonic acid, or oleum, in order to obtain, after work-up of the reaction mixture, phenothiazine-2-sulfonic acid, followed by the reduction of this or, optionally, of its acyl chloride derivative, to obtain 2-mercapto-phenothiazine which subsequently is subjected to S-alkylation to thereby obtain the desired target compound.

REFERENCES:
patent: 3136762 (1964-06-01), Mayer et al.
patent: 3413290 (1968-11-01), Renz
patent: 3625963 (1971-07-01), Lalanne
patent: 3787413 (1974-01-01), Naka
patent: 3961055 (1976-06-01), Baget
Duperray Chemical Abstracts, 59, 6418b (1963).

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