Process for the diastereoselective reductive pinacol coupling of

Details Process for the diastereoselective reductive pinacol coupling of Process for the diastereoselective reductive pinacol coupling of

1994-06-22

1995-10-31

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564154, 564153, 564157, 546265, 546146, C07C23720, C07C23532

Patent

active

054631246

ABSTRACT:
Process for the diastereoselective reductive pinacol coupling of homochiral .alpha.-aminoaldehydes
A process for the preparation of optically pure symmetrical compounds of the formula I ##STR1## is described in which R.sup.1, R.sup.2 and R.sup.3 are explained in the description, with simultaneous control of the four centers of chirality marked by *.

REFERENCES:
patent: 5142056 (1992-08-01), Kempe et al.
Kempf et al., J. Med. Chem., vol. 33, pp. 2687-2689 (1990).
Roskamp et al., J. Am. Chem. Society, vol. 109, pp. 3152-3154 (1987).
Roskamp et al., J. Am. Chem. Society, vol. 109, pp. 6551-6553 (1987).
CA116:59556c, Hartung Jack Bardair Jr., Coupling Reactions of Alkynes and Aldehydes promoted by NbCl3.DME.

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