Process for the detection of restriction fragment length polymor

Details Process for the detection of restriction fragment length polymor Process for the detection of restriction fragment length polymor

1987-09-25

1991-01-22

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 27, 935 77, 935 78, C12Q 168, C07H 1512, C12N 1500

Patent

active

049870661

ABSTRACT:
The invention is directed to a process for the analysis of eukaryotic DNA erein DNA of an individual is isolated, the DNA is subjected to restriction endonuclease digest, the cleaved DNA is separated by gel electrophoresis, the gel is dried and hybridized with a probe, and the pattern of the DNA is evaluated. The process is characterized in that the probe used is an oligonucleotide which specifically hybridizes to eukaryotic simple tandem repeats having a periodicity of 2 to 4 bases.
The process of the invention may be employed for the in vitro diagnosis of genetic defects such as hereditary diseases or for the determination of the genetic interrelationships.

REFERENCES:
Jeffreys et al., Nature, vol. 316, 76-79, 1985.
Schafer et al., Chromosoma 93, 496-501, 1986.
White, R., Trends Genet 1:177-181 (1985).
Jeffreys, A. J., et al., Nature 314:67-73 (1985).
Jeffreys, A. J., et al., Nature 317:818-819 (1985).
Epplen, J. T., et al., Proc. Natl. Acad. Sci. U.S.A. 79:3798-3802 (1982).
Schafer, R., et al., Chromosoma 93:502-510 (1986).
Kunkel, L. M. et al., Proc. Natl. Acad. Sci. U.S.A. 74:1245-1249 (1977).
Bell, G. I., et al., Nature 295:31-35 (1982).

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