Process for the depyrogenation of injectable pharmaceutical solu

Details Process for the depyrogenation of injectable pharmaceutical solu Process for the depyrogenation of injectable pharmaceutical solu

1995-05-30

1998-07-14

Fortuna, Ana

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210641, 2101952, 2102572, 210650, B01D 6100

Patent

active

057799059

ABSTRACT:
The present invention relates to a process for the preparation of injectable solutions of pharmaceutical products and/or of diagnostic agents, characterized by an extremely high degree of purity as regards the low content of bacterial endotoxins. The process of the invention provides for the prefiltering of the solutions by means of a microfiltering unit, a subsequent ultrafiltration and the recycling of the retentate from the ultrafiltration to the solution which emerges from the prefilter.

REFERENCES:
patent: 4495067 (1985-01-01), Klein et al.
patent: 4959237 (1990-09-01), Walker
patent: 5073268 (1991-12-01), Saito et al.
patent: 5104546 (1992-04-01), Filson et al.
patent: 5160437 (1992-11-01), Bosworth et al.
patent: 5171767 (1992-12-01), Buckley et al.
patent: 5219554 (1993-06-01), Groman et al.
patent: 5221485 (1993-06-01), Bosworth et al.
patent: 5385664 (1995-01-01), Oinuma et al.
patent: 5401499 (1995-03-01), Hirayama et al.

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