Process for the depletion or removal of endotoxins

Details Process for the depletion or removal of endotoxins Process for the depletion or removal of endotoxins

2006-09-19

2006-09-19

Lilling, Herbert J. (Department: 1651)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S091100, C435S262000, C435S267000, C435S270000, C536S025410

Reexamination Certificate

active

07109322

ABSTRACT:
A process for the depletion or removal of endotoxins from preparations containing active ingredients designated for therapeutical use which are obtained from natural sources by genetic engineering and/or biotechnology by treatment with chromatographic material whereinsaid natural source are lysed, the fractions obtained are optionally centrifuged, filtrated or treated with affinity chromatographic methods;said fractions are preincubated with an aqueous salt solution and detergents, treated with anion exchange material and then washed with another salt solution, and the active ingredients are eluted from the anion exchanger, followed by further purification in a per se known manner.

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