Process for the cyanation aldehydes

Details Process for the cyanation aldehydes Process for the cyanation aldehydes

2008-01-01

2008-01-01

Shameem, Golam M. M. (Department: 1626)

Catalyst, solid sorbent, or support therefor: product or process

Catalyst or precursor therefor

Organic compound containing

C502S150000, C556S042000

Reexamination Certificate

active

11114068

ABSTRACT:
A process for cyanating an aldehyde is provided. The process comprises reacting the aldehyde with:i) a cyanide source which does not comprise a Si—CN bond or a C—(C═O)—CN moiety; andii) a substrate susceptible to nucleophilic attack not comprising a halogen leaving group;in the presence of a chiral catalyst. Preferably, the chiral catalyst is a chiral vanadium or titanium catalyst. The cyanide source is preferably an alkali metal cyanide and the substrate susceptible to nucleophilic attack not comprising a halogen leaving group is a carboxylic anhydride.

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