Process for the cyanation aldehydes

Details Process for the cyanation aldehydes Process for the cyanation aldehydes

2008-01-01

2008-01-01

Shameem, Golam M. M. (Department: 1626)

Catalyst, solid sorbent, or support therefor: product or process

Catalyst or precursor therefor

Organic compound containing

C502S150000, C556S042000

Reexamination Certificate

active

07314844

ABSTRACT:
A process for cyanating an aldehyde is provided. The process comprises reacting the aldehyde with:i) a cyanide source which does not comprise a Si—CN bond or a C—(C═O)—CN moiety; andii) a substrate susceptible to nucleophilic attack not comprising a halogen leaving group;in the presence of a chiral catalyst. Preferably, the chiral catalyst is a chiral vanadium or titanium catalyst. The cyanide source is preferably an alkali metal cyanide and the substrate susceptible to nucleophilic attack not comprising a halogen leaving group is a carboxylic anhydride.

REFERENCES:
patent: 4336206 (1982-06-01), Miindnich et al.
patent: 5508458 (1996-04-01), Zhao
patent: 5756803 (1998-05-01), Casse et al.
patent: 6204406 (2001-03-01), Mori et al.
patent: 6339159 (2002-01-01), Kobayashi et al.
patent: 0 561 637 (1993-09-01), None
patent: 6-27-1522 (1994-09-01), None
patent: 7-70040 (1995-03-01), None
patent: WO 96/24601 (1996-08-01), None
Chen et al,J. Am. Chem. Soc., 122:9542-9543 (2000).
Tian et al,J. Am. Chem. Soc., submitted Mar. 15, 2001.
Sumitomo Chemical Co., E 19. 1991-096042/14 (U.S. 6,204,406).
Hashashima et al,J. Am. Chem. So., 122:7412-7413 (2000).
Hamashima et al,Tetrahedron Letters, 42:691-694 (2001).
Ichihara,Tetrahedron Letters, 42:695-697 (2001).
Belokon, et al., The Asymmetrical Addition of Trimethylsilyl Cyanide to Aldehydes Catalyzed by Chiral (Salen) Titanium Complexes, Journal of the American Chemical Society, 121:3968-3973 (1999).
Nakajima et al., “Preparation and Characterization of Optically Active Schiff Base-Oxovanadium(IV) and -Oxovanadium(V) Complexes and Catalytic Properties of These Complexes on Asymmetric Oxidation of Sulfides into Sulfoxides with Organic Hydroperoxides”, Bull. Chem. Soc. Jpn., 63(9):2620-2630 (1990).
Belokon et al., “The Asymmetric Additon of Trimethylsilyl Cyanide to Aldehydes Catalyzed by Chiral (Salen) Titanium Complexes”, J. Am. Chem. Cos., 121:3968-3973 (1999).

Affiliated with

Also associated with

Rating

Process for the cyanation aldehydes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the cyanation aldehydes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the cyanation aldehydes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2794249