Process for the crystallization of a reverse transcriptase inhib

Details Process for the crystallization of a reverse transcriptase inhib Process for the crystallization of a reverse transcriptase inhib

1998-01-20

1999-10-12

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D26518

Patent

active

059657294

ABSTRACT:
The instant invention describes a method for crystallizing (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-ben zoxazin-2-one from a solvent and anti-solvent solvent system and producing the crystalline product. The desired final crystal form, Form I, can be produced when using methanol or ethanol. Form II is isolated from 2-propanol and can be converted to the desired crystal form at low drying temperatures, such as between about a temperature of 40.degree. C. and 50.degree. C.

REFERENCES:
patent: 5519021 (1996-05-01), Young et al.
patent: 5633405 (1997-05-01), Thompson et al.
patent: 5663467 (1997-09-01), Thompson et al.

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