Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-10-28
1999-01-12
Rotman, Alan L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
514381, C07D25704, A61K 3114
Patent
active
058592580
ABSTRACT:
Losartan potassium is an angiotensin II antagonist useful in the treatment of hypertension and congestive heart failure. ##STR1## This invention relates to the process for the controlled crystallization of losartan potassium utilizing anti-solvent addition combined with massive seeding in order to obtain the desired crystal morphology and bulk physical properties necessary for successful formulation.
REFERENCES:
patent: 5130439 (1992-07-01), Lo et al.
patent: 5138069 (1992-08-01), Carini et al.
patent: 5206374 (1993-04-01), Lo
patent: 5310928 (1994-05-01), Lo et al.
patent: 5608075 (1997-03-01), Campbell, Jr. et al.
Breen Patrick
Dienemann Erik A.
Epstein Albert D.
Kennedy Michael T.
Larson Karen A.
Aulakh Charanjit S.
Camera Valerie J.
Daniel Mark R.
Garcia-Rivas J. Antonio
Merck & Company, Inc.
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