Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1981-06-04
1984-08-21
Jiles, Henry R.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260455R, 568 62, 568 67, 2602452T, 2602452R, C07C14918, C07C15301, C07C153017, C07C153023
Patent
active
044669143
ABSTRACT:
Disclosed is a mild, efficient, stereo-selective process for a one step conversion of primary and secondary alcohols to their corresponding thiol ester and thiol derivatives with inversion of configuration. The process comprises the reaction of the alcohol in question (4), the thiolacid of choice (5) in the presence of adduct 3; the resulting thiol ester 6 may be converted to the free thiol 7 by hydrolysis or reductive methods: ##STR1##
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Hazen George G.
Volante Ralph P.
Jiles Henry R.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Szura Daniel T.
Whittenbaugh Robert C.
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