Process for the conversion of 6-aminopenicillanic acid (6-APA) i

Details Process for the conversion of 6-aminopenicillanic acid (6-APA) i Process for the conversion of 6-aminopenicillanic acid (6-APA) i

1975-10-30

1977-11-15

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D50110

Patent

active

040586600

ABSTRACT:
A process consisting in reacting one mole of an alpha-halobenzyl penicillin-(s)-sulphoxide with at least two moles of 3-trimethylsilyl-2-oxazolidinone (TMSO) at a temperature of between 60 and 120.degree. C in acetonitrile solution in the presence of a tertiary organic base p-toluene sulphonate and thiourea is described. The solvent is removed by evaporation from the solution obtained, the residue is diluted with water, the pH is adjusted to 4.2 and 7-aminodesacetoxycephalosporanic acid (7-ADCA) is isolated.

REFERENCES:
patent: 3766177 (1973-10-01), Webber et al.
patent: 3879398 (1975-04-01), Ellerton et al.
patent: 3932387 (1976-01-01), Kulolya et al.
patent: 3932398 (1976-01-01), Nudelman et al.
patent: 3947465 (1976-03-01), Coll
patent: 3953440 (1976-04-01), Hatfield

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