Process for the controlled production of organic particles

Details Process for the controlled production of organic particles Process for the controlled production of organic particles

2011-01-25

2011-01-25

Wax, Robert A (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S400000, C264S005000

Reexamination Certificate

active

07875295

ABSTRACT:
A process for the production of a microparticle or a nanoparticle of a chemical compound comprising the steps of providing a solution of said chemical compound in a first liquid; providing a second liquid in which said chemical compound is insoluble or substantially insoluble; combining said liquids in a region of high shear thereby causing formation of said particles; and isolating said particles of said compound. The processing time of a coacervation style process can be reduced and the yield can be substantially increased both by control of the precipitation step which allows for desolvation step to be dispensed with leading to significant process time reduction. The invention also provides a molecular mixing unit comprising an outer body defining a mixing zone; a shear means to provide shear liquid in said mixing zone; at least one fluid inlet means for a first liquid; at least one fluid inlet means for a second liquid and a fluid outlet means.

REFERENCES:
patent: 4282209 (1981-08-01), Tocker
patent: 5510118 (1996-04-01), Bosch et al.
patent: 5622657 (1997-04-01), Takada et al.
patent: WO 00/18371 (2000-04-01), None
patent: WO 01/14036 (2001-03-01), None

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